What to know about cychlorphine, the synthetic opioid 10 times stronger than fentanyl

The Hill
by Colin Meyn
March 12, 2026
2 views
2 min read

Quick Insights

The Bottom Line

Cychlorphine, a new synthetic opioid 10 times stronger than fentanyl, is causing overdoses in the U.S.

How This Affects You

This new opioid, cychlorphine, poses an increased risk of overdose, as it is 10 times stronger than fentanyl and mixed into other drugs.

AI Summary

Multiple states have issued warnings regarding cychlorphine, a synthetic opioid linked to several dozen recent overdoses. This substance is ten times stronger than fentanyl and is part of a new class of synthetic opioids entering the U.S. illicit drug supply. Cychlorphine has never been approved for human use and, like fentanyl, is being mixed into other drugs. The documented consequences include multiple overdose incidents across various states.

What's Being Done

Multiple states have issued warnings regarding cychlorphine due to overdose incidents.

Should this be getting more attention?

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